Speakers
Xavier Griffin
Alexia Karantana
Rebecca Kearney
Andrew McCaskie
Stephen McDonnell
Dan Perry
Emma Reay
Ines Reichert
BOA Session
BIG Trials BIG News
Chair: Andrew McCaskie, Co-Chair: Ines Reichert
Agenda:
Introduction Andrew McCaskie
Big Trials, New Findings - Chair: Dan Perry (30 minutes)
- The POINT Trial: A multi-centre randomised trial of surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults Alexia Karantana
- Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial Rebecca Kearny
- Q&A Chair: Ines Reichert
Big Trials, Coming Soon - Chair: Andrew McCaskie (60minutes)
- TILLI Trial and trauma Xavier Griffin
- PORTRAIT - Radiotherapy after fixation of pathological bone lesions RCT Joanathan Stevenson
- ACLSTAR - ACL repair RCT Stephen McDonnell
- SCOOT - Thumb base OA RCT Emma Reay
- Paediatric trial Dan Perry
- Q&A Chair: Ines Reichert
Professor Xavier Griffin spearheads academic orthopaedics at Queen Mary and Barts Health, having joined in August 2020 as the inaugural chair of Bone and Joint Health.
Xavier’s vision is for world class excellence in research and clinical academic training; providing opportunity for the next generation of clinician scientists to realise their aspirations.
Xavier is a NIHR Clinician Scientist and has been awarded over £10m of research funding and over 80 peer reviewed publications.
He is driven by having a meaningful impact on patient care; his research is focused on the clinical and cost-effectiveness of new and existing treatments to improve bone and joint health and has been cited by the National Institute of Clinical Excellence. He has a passion for developing methodologies that harness the speed, power, and efficiency of routinely-collected data but are coupled with the great advantages of randomisation.
Alexia is a consultant hand and orthopaedic surgeon and joined the University of Nottingham in 2015 as a clinical academic. Her research focus is musculoskeletal randomised controlled trials, core outcome set development and research prioritisation in hand surgery. As part of her role, she is embedded within the Nottingham Clinical Trials Unit. Alexia is currently Research Committee Chair for the British Society for Surgery of the Hand (BSSH) and has previously led the Centre for Evidence Based Hand Surgery (2019-2024) in Nottingham, working in collaboration with the BSSH and the Scar Free Foundation.
Rebecca is Professor and Director of Bristol Trials Centre, within Bristol Medical School. She is a NIHR Senior Investigator and academic physiotherapist leading in the design and delivery of clinical trials. Her primary focus is pragmatic multi centre randomised controlled trials that evaluate the clinical and cost effectiveness of rehabilitation interventions in the area of trauma and orthopaedics. To ensure that patients and public members are at the heart of her programmes of research she has also been a member of four ‘James Lind Alliance Priority Setting Partnerships’.
Rebecca is currently co-chair for NIHR Programme Grants for Applied Research and has previously been regional chair for NIHR Research for Patient Benefit (2021-2023). She has also previously been a committee member on NIHR Health Technology Assessment (2018-2022), NIHR ICA Doctoral Fellowships (2017-2021) and NIHR Research for Patient Benefit (2016-2019).
Professor Andrew McCaskie is Professor of Orthopaedic Surgery and Interim Deputy Head of the School of Clinical Medicine (following this he will resume the role as Head of the Department of Surgery) at the University of Cambridge and Honorary Consultant at Addenbrookes’ Hospital.
His clinical interest is lower limb, particularly hip disease in young adults. His translational research is focused on cell and regenerative therapies relating to bone and cartilage repair. This encompasses work to understand the role of cells and molecules in repair, alongside advanced imaging, related clinical trial work, precision health approaches and patient stratification.
He is Director of the Versus Arthritis Tissue Engineering and Regenerative Therapies Centre, which brings together several UK institutions and is a Principal Investigator at the Cambridge Stem Cell Institute.
He is a past president of the Association of Professors of Orthopaedic Surgery and the British Orthopaedic Research Society and has served on the British Editorial Society of Bone & Joint Surgery Council of Management. He is the current Chair of the Research Committee of the BOA. He is an editor for Bailey and Love’s Short Practice of Surgery (27th & 28th Editions) and was inducted a Fellow of International Orthopaedic Research in 2019.
Stephen McDonnell is an Associate Professor at the University of Cambridge and an Honorary Consultant Knee Surgeon. His research interests are Knee injuries, identifying and stratifying patients with early knee osteoarthritis, and defining their phenotypic features.
His interests in Knee injuries include prevention, stratification tools, and treatments. He has led the James Lind Alliance for the priorities in Soft tissue knee injuries; he is currently undertaking work developing the CamKIT - Cambridge Knee Injury Toolkit. He leads an NIHR Multi Centre International randomised control trial, ACL STARR, for ACL repair vs. ACL reconstruction.
He works closely with the Department of Radiology using novel imaging techniques. This aims to provide a personalised treatment for the different phenotypes of early knee OA. He was the centre coordinator for the EU ADIPOA2 clinical trial investigating the safety and efficacy of autologous adipose-derived stem cells in the treatment of advanced OA of the knee and the PI for EU Starstem project understanding how to stem cells and extracellular vesicles lead to healing using photoacoustic imaging techniques. He undertook his previous research MD and orthopaedic surgical training in Oxford, based at the Nuffield Orthopaedic Centre.
He remains a busy clinical knee surgeon treating children's and adult knee injuries. He undertook a specialist knee and hip “Sports and Joints” fellowship in Melbourne with the Melbourne Orthopaedic Group.
Daniel Perry MA(Oxon), PhD, FRCS (Orth) FRCS Ed (Ad Hominem) is an NIHR Research Professor, Consultant Children's Orthopaedic Surgeon at Alder Hey Children’s Hospital and is the BOA Speciality Lead for Paediatric Orthopaedic Clinical Trials.
Dan trained in Liverpool and Warwick, before completing a fellowship at SickKids Hospital, Toronto, Canada. He is the first orthopaedic surgeon to have been awarded a prestigious NIHR Research Professorship.
Dan leads a large amount of research in children’s trauma, orthopaedics and emergencies – including orthopaedic studies - FORCE, SCIENCE, CRAFFT, BigBOSS, PICBONE, ODDSocks, OpNonSTOP, BASIS and even a trial in paediatrics about UTIs (CURLY)! His academic love is to make clinical research accessible – for children, parents and clinicians. He keenly integrates cartoons, animations, videos and uses text messages to make trials easy for everyone.
Dan is a member of the NIHR HTA General Board, is Orthopaedic trials lead for the Royal College of Surgeons, an Editor of the Bone and Joint Journal and is the clinical lead for hip screening within Public Health England.
Emma Reay is a Consultant Hand and Wrist Surgeon working at James Cook University Hospital in Middlesbrough. She trained in the North East of England and undertook fellowships in the UK and Australia and completed the UK Diploma in Hand Surgery. She is the Surgical Specialty Lead for Hand Surgery for the UK for the BSSH and the RCS. She is currently Co-Chief Investigator for two NIHR funded RCTs in Hand surgery and is a member of the BSSH Research Committee.
Alongside her role in promoting research in Hand Surgery she has recently led the Orthopaedic Department at South Tees as Clinical Director and during that time completed an MBA. She has a keen interest surgical training and has been Training programme Director for Orthopaedic Core Trainees in the Northern Region, is a member of the Trauma and Orthopaedic SAC and is an invited speaker and faculty member on a number of surgical training courses.
PhD in Fracture Healing and Bone Blood Flow at Imperial College prior to her Orthopaedic Training in the KSS / South-East London Region. Since continued interest in research with focus on fracture treatment, post-traumatic OA and the effect of comorbidities, in particular diabetic neuropathy, on bone biology. Clinical Research: conduct and delivery of NIHR portfolio trials, Undergraduate teaching. Active member of BORS, ORS / ISFR. Clinical Sub-specialities Hand & Wrist / Diabetic Foot / Trauma.
Jonathan Stevenson is a specialist in orthopaedic oncology & arthroplasty at the Royal Orthopaedic Hospital, Birmingham. After graduating from the University of Birmingham with degrees in biomedical sciences and medicine in 2005, he undertook postgraduate orthopaedic training on the Stoke/Oswestry rotation in the West Midlands. He was awarded the British Orthopaedic Association (BOA) International travelling fellowship award, the British Orthopaedic Oncology Society European travelling fellowship award and the American-British-Canadian travelling fellowship. He has also completed the BOA clinical leadership programme and was awarded a certificate in strategic management and leadership.
Jonathan specialises in paediatric and adult bone and soft-tissue sarcomas, limb-salvage and complex arthroplasty, particularly prosthetic joint infection. He is a senior honorary clinical lecturer in orthopaedics at Aston University. Jonathan is chief/principal investigator on studies concerning metastatic bone disease, osseointegration of endoprosthetic replacements and bacterial fluorescence in PJI and clinical lead for sarcoma genomics, metastatic bone disease and the research tissue bank.
He is also clinical lead for the Bone Metastasis Research Collaborative (BMRC) and a trustee for the Bone Cancer Research Trust (BCRT) leading on awareness and early diagnosis in bone sarcomas. In addition to his clinical work, Mr. Stevenson has presented research at an international level since 2010 and is a reviewer for multiple orthopaedic and oncology journals. He has published greater than 100 peer reviewed scientific articles with over 1000 citations, six book chapters and is the co-editor of an orthopaedic basic sciences textbook. Due to his experience, he regularly examines and lectures on FRCS (Tr & Orth) courses.